Non alcoholic fatty liver disease (NAFLD) is a kind of metabolic disease whose pathogenesis is still unclear. The main causes include high fat diet, obesity, insulin resistance, diabetes, etc. The establishment of NAFLD animal models has become the main carrier for studying its pathogenesis and developing new drugs. The animal model of this disease prepared by high-fat emulsion gavage has begun to be used for research on this disease.

A rat model of non-alcoholic fatty liver disease

A mouse model of non-alcoholic fatty liver disease

Observation indicators

The levels of ALT and AST significantly increased; The surface color of the rat liver is earthy yellow and greasy. HE staining shows a large number of fat vacuoles in its liver cells, disordered tissue texture, severe damage to liver lobular structure, and inflammatory cell infiltration.

Partial Results Display