Myocardial infarction refers to ischemic necrosis of the myocardium, which is an acute and severe cardiac condition. The realization of the function of the heart as a center of blood circulation dynamics requires continuous blood supply from the coronary artery. When the coronary artery becomes diseased and narrows or blocks, causing a sharp decrease or interruption in blood flow, it will lead to severe and persistent acute ischemia of the corresponding myocardium. The myocardium cannot receive enough oxygen, ultimately leading to irreversible ischemic necrosis of the myocardium, reduced contraction and relaxation function of the heart, insufficient blood supply to the body, and in severe cases, ultimately leading to death. Ligation of the left anterior descending coronary artery can cause coronary artery stenosis or occlusion in model animals, leading to myocardial ischemia and necrosis of the myocardium supplied by the coronary artery, thereby causing myocardial infarction in the model animals.

A rat model of myocardial infarction

Myocardial infarction mouse model

Observation indicators

Cardiac ultrasound detection of EF, left ventricular end diastolic diameter (LVEDD), and left ventricular end systolic diameter (LVESD); Masson staining or Sirius red staining were used to observe myocardial tissue fibrosis, while Evans blue TTC staining was used to observe infarct size; HE staining to observe pathology; ELISA detects inflammatory factors such as TNF - α, IL-1 β, and IL-6 in serum.

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