Xenograft transplantation models can be divided into two categories based on the different types of transplants: cell line derived xenograft (CDX) and patient derived xenograft (PDX). CDX model: Human derived tumor cells are cultured in vitro and transplanted subcutaneously into mice for pharmacodynamic evaluation or mechanism research. It is currently one of the most commonly used in vivo models for preclinical pharmacodynamic evaluation of anti-tumor drugs. Its advantages are that it can be transplanted in large quantities under the same conditions, the experimental cycle is short, the success rate of modeling is high, and the treatment mechanism for animals is similar to that of humans. It has become the most widely used modeling method currently.

This model involves injecting tumor cells subcutaneously or under the armpits of mice to grow into tumors, which can be used for tumor related mechanisms and drug development.